Gene Ontology
Gene ontology is used to organize genes based on several properties pertaining to gene products. The ontology covers three domains: cellular component, the parts of a cell or its extracellular environment; molecular function, the elemental activities of a gene product at the molecular level, such as binding or catalysis; and biological process, operations or sets of molecular events with a defined beginning and end, pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms.[1]
Cellular Component
Molecular Function
Biological Process
Summary
Properties listed multiple times indicate multiple references from various sources. This is a good indicator of relevance and importance of each property with regard to the CDH1 gene product. Using this criteria, it becomes apparent that cadherin-1 is involved cell-cell adhesion in a homophilic manner (cdh1-cdh1). Cadherin-1 can be found most often on the plasma membrane, specifically at cell-cell junctions. Cadherin-1 is likely involved in calcium-dependent protein binding at these junctions.
Below is a tree encompassing all of the gene ontology properties listed on AmiGO.
Below is a tree encompassing all of the gene ontology properties listed on AmiGO.
GO Tree of CDH1
(click image above to view larger version of GO tree)
References
1. geneontology.org
2. http://www.ebi.ac.uk/QuickGO/GProtein?ac=P12830
1. geneontology.org
2. http://www.ebi.ac.uk/QuickGO/GProtein?ac=P12830