Regions
Domains
Cadherin prodomain (pfam08758)
This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions. Cadherins are activated through cleavage of the prosequence in the late Golgi.[4]
This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions. Cadherins are activated through cleavage of the prosequence in the late Golgi.[4]
Cadherin domain (cd11304)
Cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration. [5]
Cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration. [5]
Cadherin cytoplasmic region (pfam01049)
Conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region (the part of the cytoplasmic region which is adjacent to the transmembrane domain) of the cadherin. This region induces clustering and also binds to the protein catenin.[6] The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of cadherin-1, possibly through interaction with the cytoskeleton.[7]
Conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region (the part of the cytoplasmic region which is adjacent to the transmembrane domain) of the cadherin. This region induces clustering and also binds to the protein catenin.[6] The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of cadherin-1, possibly through interaction with the cytoskeleton.[7]
References
1. http://www.uniprot.org/uniprot/P12830
2. http://pfam.sanger.ac.uk/ncbiseq/4757960
3. http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi
4. http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?ascbin=8&maxaln=10&sel&uid=198895
5. http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?ascbin=8&maxaln=10&sel&uid=206637
6. http://www.ncbi.nlm.nih.gov/pubmed/9566976
7. http://www.ncbi.nlm.nih.gov/pubmed/3061804
1. http://www.uniprot.org/uniprot/P12830
2. http://pfam.sanger.ac.uk/ncbiseq/4757960
3. http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi
4. http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?ascbin=8&maxaln=10&sel&uid=198895
5. http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?ascbin=8&maxaln=10&sel&uid=206637
6. http://www.ncbi.nlm.nih.gov/pubmed/9566976
7. http://www.ncbi.nlm.nih.gov/pubmed/3061804